I used to use AdBlock+ and uBlock, but since AdBlock+ started whitelisting ads for a profit, I've been using uBlock Origin. I have had better performance and website responsiveness since switching over.

I like to be able to customize my blocking preferences. I don't like having to open up another tab and then reload a page to see what content is being blocked. If a list of blocked content was shown similar to PrivacyBadger by EFF, it would be easier to troubleshoot any rules that break a webpage (which would in turn make it easier to fix via GitHub pull requests).

Overall, amazing add-on for Firefox!